2018－2019 | Publicly Invited Research | Living in Space - Integral Understanding of life-regulation mechanism from "SPACE" | Grant-in-Aid for scientific Research on Innovative Area(2015-2019), MEXT, Japan

2018－2019 Publicly Invited Research

A01 Molecular and Cellular Foundations of Gravity Responses

Research Subject	Molecular analyses on the common physiological aspects of astronauts and bed-ridden old patients.
Research Group Leader	Toshihiko Ogura Professor, Institute of Development, Aging and Cancer Tohoku University Website https://www.med.tohoku.ac.jp/nsgcoe/en/eng/member/ogura/

Research Subject	A novel mechanism for regulating plant root growth under different gravitational conditions in space
Research Group Leader	Hideyuki Takahashi Professor, Graduate School of Life Sciences, Tohoku University Website http://www.ige.tohoku.ac.jp/tekio/ (*Written in Japanese)

Research Subject	Elucidation of muscle atrophy mechanism from space environment
Research Group Leader	Satoru Takahashi Professor, Faculty of Medicine, University of Tsukuba Website http://www.md.tsukuba.ac.jp/basic-med/anatomy/embryology/index_e.html

Research Subject	Robustness of tissue organization and cell structure against gravity or physical force
Research Group Leader	Tatsuo Michiue Professor, Graduate School of Arts and Sciences, the University of Tokyo Website http://www.park.itc.u-tokyo.ac.jp/michiuelab/ (*Written in Japanese)

Research Subject	Mesenchymal stem cells as mechanosensor
Research Group Leader	Eiichi Hinoi Professor, Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University Website http://www.gifu-pu.ac.jp/info/organization/list/yakuri/ (*Written in Japanese)

Research Subject	Artificial models for gravity-sensitive cytoplasm
Research Group Leader	Kanta Tsumoto Associate Professor, Graduate School of Engineering, Mie University Website http://www.bio.chem.mie-u.ac.jp/ (*Written in Japanese)

Research Subject	Mechanism of microgravity sensing in muscle mitochondria
Research Group Leader	Takeshi Nikawa Professor, Department of Nutritional Physiology, Institute of Medical Nutrition, Tokushima University Graduate School Website https://tokudai-seitaieiyo.jimdo.com/ (*Written in Japanese)

Research Subject	Elucidation of a new mechanism in bone metabolism using the changes of gravity vector/parameter
Research Group Leader	Masahiro Chatani Assistant Professor, Department of Pharmacology, School of Dentistry, Showa University Website https://sites.google.com/view/masahiro-chatani (Written in Japanese) http://www10.showa-u.ac.jp/~dpharmc/index.html (Written in Japanese)

Research Subject	Study on effects of the space environment on brain structures and functions of model vertebrate zebrafish
Research Group Leader	Koichi Kawakami Professor, National Institute of Genetics Website https://www.nig.ac.jp/nig/ja/ (*Written in Japanese) http://ztrap.nig.ac.jp

Research Subject	Identification of mechanisms underlying impacts of space environment on lymphoid tissues
Research Group Leader	Taishin Akiyama Team Leader, RIKEN Center for Integrative Medical Sciences Website http://www.riken.jp/en/research/labs/ims/immun_homeost/

Research Subject	The importance of mechanical signals on homeostasis of skeletal muscle and peripheral circulation.
Research Group Leader	Takuro Numaga-Tomita Associate Professor, Molecular Pharmacology, Graduate School of Medicine, Shinshu University

A02 Influence of a Prolonged Stay in Space on Higher-order Homeostasis

Research Subject	Role of osteocyte PI3K in regulation of bone homeostasis
Research Group Leader	Masahiro Shinohara Section Chief, Molecular Pathophysiology Section, Department of Rehabilitation for the Movement Functions, Research Institute National Rehabilitation Center for Persons with Disabilities

Research Subject	Elucidation and manipulation of the neural mechanisms underlying the circadian period determination
Research Group Leader	Michihiro Mieda Professor, Department of Integrative Neurophysiology, Graduate School of Medical Sciences, Kanazawa University Website http://neurophysiol.w3.kanazawa-u.ac.jp/ (*Written in Japanese)

Research Subject	The immunological memory under the alteration of gravity as an extreme stress ―Regulation and failure of its establishment, maintenance and re-activation―
Research Group Leader	Yoichi Maekawa Professor, Gifu University Graduate School of Medicine Domain Leader, G-CHAIN, Gifu University Website http://www.med.gifu-u.ac.jp/labo/parasite/index.html (*Written in Japanese)

Research Subject	Plastic alteration of autonomic nervous system induced by gravitational change: Communication between vestibular system and C1 neurons in medulla oblongata
Research Group Leader	Chikara Abe Associate Professor, Gifu University Graduate School of Medicine Website http://www.med.gifu-u.ac.jp/labo/physiol/ (*Written in Japanese)

Research Subject	Analysis of combined influence by possible physical stresses in a closed space and development of method of protection for health risks
Research Group Leader	Nobutaka Ohgami Lecturer, Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine

Research Subject	New approach for exercise epigenetics based on the acceleration-sensing in skeletal muscle
Research Group Leader	Fuminori Kawano Associate Professor, Graduate School of Health Sciences, Matsumoto University Website https://www.matsumoto-u.ac.jp/professors/pid00234.php (*Written in Japanese)

Research Subject	Elucidation of the new bone homeostasis maintained by gravitational loading
Research Group Leader	Haruko Takano Senior Researcher, Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute Website http://www.ncvc.go.jp/english/res/str_ana/

A03 Environmental Risks Expected in Space

Research Subject	Role of Environmental Stress-responsive Transcription Factor Nrf2 in Space Stress
Research Group Leader	Takafumi Suzuki Senior Assistant Professor, Department of Medical Biochemistry, Tohoku University Graduate School of medicine Website http://www.dmbc.med.tohoku.ac.jp/official/index.html (*Written in Japanese)

Research Subject	Development of a novel PDMS-based micro-nano device for evaluation of biological risk in Space
Research Group Leader	Asako Nakamura Professor, Collage of Science, Ibaraki University Website http://asakolab.sci.ibaraki.ac.jp/index.html (*Written in Japanese)

Research Subject	Analysis of the difference in radiation tolerability among organs; toward the development of strategies against space radiation
Research Group Leader	Hiroshi Harada Professor, Radiation Biology Center, Graduate School of Biostudies, Kyoto University Website http://www.rbc.kyoto-u.ac.jp/cancer_biology/ (*Written in Japanese)

Research Subject	The effect of space radiation in vascular endothelial cell through micronuclei formation
Research Group Leader	Junya Kobayashi Professor, Department of Radiological Sciences, International University of Health and Welfare Graduate School Website https://www.iuhw.ac.jp/daigakuin/staff/cat/cat10/9187.html (*Written in Japanese)

Research Subject	Genetic basis underlying the individual differences in rasiosensitivity within human populations for the future radiological protection in Space
Research Group Leader	Tatsuo Miyamoto Associate Professor, Department of Genetics and Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University Website https://home.hiroshima-u.ac.jp/genome/ (*Written in Japanese)

Research Subject	Development of method for irradiating various biological targets with focusing heavy-ion microbeam for space radiation research
Research Group Leader	Tomoo Funayama Senior Principal Researcher, Takasaki Advanced Radiation Research Institute, Quantum Beam Science Research Directorate, National Institute for Quantum and Radiological Science and Technology Website http://www.taka.qst.go.jp/rab_div/en/mrb/index_e.html

Research Subject	Estimation of carcinogenic risk after exposure to space radiation by pathological and genomic analyses
Research Group Leader	Shizuko Kakinuma Deputy Director General, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology Website https://www.qst.go.jp/site/nirs-english/1366.html

B01 Cross-sectional/complementary studies

Research Subject	Hypothermia as a risk factor for memory consolidation
Research Group Leader	Michael Lazarus Associate Professor, International Institute for Integrative Sleep Medicine, University of Tsukuba Website http://www.wpiiiislazaruslab.org

Research Subject	Cross-sectional analysis of latent infections for the space development
Research Group Leader	Akihisa Kato Associate Professor, Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science The University of Tokyo Website http://www.ims.u-tokyo.ac.jp/Kawaguchi-lab/KawaguchiLabTop.html (*Written in Japanese)

Research Subject	Elucidation of molecular machinery preventing extreme environmental stress
Research Group Leader	Takekazu Kunieda Associate Professor, Graduate School of Science, University of Tokyo Website http://www.bs.s.u-tokyo.ac.jp/~saibou/kuma/ (*Written in Japanese)

Research Subject	Establishment of a design guideline for material recycling plant factory for maintaining human healthy life in long-term manned space activities
Research Group Leader	Yoshiaki Kitaya Professor, Graduate School of Life and Environmental sciences, Osaka Prefecture University Website http://envbio.envi.osakafu-u.ac.jp/staff/kitaya (*Written in Japanese)

Research Subject	Visualizing cell function dynamics in virtual outer space
Research Group Leader	Asako Sakaue-Sawano Laboratory for Cell Function Dynamics, Center for Brain Science, RIKEN Website http://cfds.brain.riken.jp/Fucci.html