Role of Environmental Stress-responsive Transcription Factor Nrf2 in Space Stress – Publicly Invited Research 2018－2019

  1. A01 Ogura
  2. A01 H. Takahashi
  3. A01 S. Takahashi
  4. A01 Michiue
  5. A01 Hinoi
  6. A01 Tsumoto
  7. A01 Nikawa
  8. A01 Chatani
  9. A01 Kawakami
  10. A01 Akiyama
  11. A01 Tomita
  1. A02 Shinohara
  2. A02 Mieda
  3. A02 Maekawa
  4. A02 Abe
  5. A02 Ohgami
  6. A02 Kawano
  7. A02 Takano
  1. A03 Suzuki
  2. A03 Nakamura
  3. A03 Harada
  4. A03 Kobayashi
  5. A03 Miyamoto
  6. A03 Funayama
  7. A03 Kakinuma
  1. B01 Lazarus
  2. B01 Kato
  3. B01 Kunieda
  4. B01 Kitaya
  5. B01 Sawano
Research Subject Role of Environmental Stress-responsive Transcription Factor Nrf2 in Space Stress
Research Group Leader
name
Research Collaborator(s)
  • Masayuki Yamamoto
    Professor, Department of Medical Biochemistry, Tohoku University Graduate School of medicine

Space flight brings an extreme environment with unique stressors. For instance, exposure to cosmic radiation increases intracellular oxidative stresses, which lead to DNA damage and cell death. Microgravity provokes cellular mechanical stresses and perturbs cellular signaling, leading to reduction of muscle and bone density. To overcome the space stresses, one of the promising strategies is to activate Nrf2, a master regulator of antioxidant pathway. This study will send genetically modified loss-of-Nrf2-function mice to space and examine how Nrf2 contributes to effective prevention against the space-originated stresses.