Analysis of the difference in radiation tolerability among organs; toward the development of strategies against space radiation – Publicly Invited Research 2018－2019

  1. A01 Ogura
  2. A01 H. Takahashi
  3. A01 S. Takahashi
  4. A01 Michiue
  5. A01 Hinoi
  6. A01 Tsumoto
  7. A01 Nikawa
  8. A01 Chatani
  9. A01 Kawakami
  10. A01 Akiyama
  11. A01 Tomita
  1. A02 Shinohara
  2. A02 Mieda
  3. A02 Maekawa
  4. A02 Abe
  5. A02 Ohgami
  6. A02 Kawano
  7. A02 Takano
  1. A03 Suzuki
  2. A03 Nakamura
  3. A03 Harada
  4. A03 Kobayashi
  5. A03 Miyamoto
  6. A03 Funayama
  7. A03 Kakinuma
  1. B01 Lazarus
  2. B01 Kato
  3. B01 Kunieda
  4. B01 Kitaya
  5. B01 Sawano
Research Subject Analysis of the difference in radiation tolerability among organs; toward the development of strategies against space radiation
Research Group Leader
name
Hiroshi Harada
Professor, Radiation Biology Center, Graduate School of Biostudies, Kyoto University
Website
http://www.rbc.kyoto-u.ac.jp/cancer_biology/ (*Written in Japanese)
Research Collaborator(s)
  • Shizuko Kakinuma
    Director, Department of Radiation Effects Research, NIRS, QST
  • Asako Nakamura
    Professor, College of Science, Ibaraki University
  • Chizuru Tsuruoka
    Researcher, Department of Radiation Effects Research, NIRS, QST
  • Minoru Kobayashi
    Postdoctoral Fellow, Graduate School of Biostudies, Kyoto University
  • Sho Koyasu
    Visiting Scientist, Graduate School of Biostudies, Kyoto University

Several lines of research have reported that radiosensitivity of cells is different among organs; the notion is based on the so-called Bergonie-Tribondeau's law. However, it remains largely unclear how and why the efficiencies of both generation and repair of DNA damage are influenced by tissue microenvironments. In our project, we aim at analyzing the diversity of the radiation-induced DNA damage responses among major organs by the use of genetically-engineered mice which enable us to monitor DNA double-strand breaks in real-time. In addition, we aim to identify novel gene networks responsible for the diversity. An ultimate goal of our project is to comprehensively understand the impact of space radiation on our body for the development of strategies to overcome space radiation.