Identification of mechanisms underlying impacts of space environment on lymphoid tissues – Publicly Invited Research 2018－2019

  1. A01 Ogura
  2. A01 H. Takahashi
  3. A01 S. Takahashi
  4. A01 Michiue
  5. A01 Hinoi
  6. A01 Tsumoto
  7. A01 Nikawa
  8. A01 Chatani
  9. A01 Kawakami
  10. A01 Akiyama
  11. A01 Tomita
  1. A02 Shinohara
  2. A02 Mieda
  3. A02 Maekawa
  4. A02 Abe
  5. A02 Ohgami
  6. A02 Kawano
  7. A02 Takano
  1. A03 Suzuki
  2. A03 Nakamura
  3. A03 Harada
  4. A03 Kobayashi
  5. A03 Miyamoto
  6. A03 Funayama
  7. A03 Kakinuma
  1. B01 Lazarus
  2. B01 Kato
  3. B01 Kunieda
  4. B01 Kitaya
  5. B01 Sawano
Research Subject Identification of mechanisms underlying impacts of space environment on lymphoid tissues
Research Group Leader
name
Taishin Akiyama, Ph.D.
Team Leader, RIKEN Center for Integrative Medical Sciences
Website
http://www.riken.jp/en/research/labs/ims/immun_homeost/

Space flight will become common in near future. When travelling in space, human experiences unusual environment such as microgravity and high dose of space radiation that are far from earth environment. Moreover, human feels emotional stress due to possible dangers in space and fear of confined place during space flight. These environmental change and emotional stress during space flight should influence on human physiology. Therefore, impacts of space flight on the body and their cellular and molecular mechanisms should be elucidated. In addition, based on such information, methods preventing unfavorable effects should be developed if necessary.  

Environmental changes and stressors influences functions of immune systems. Previous studies showed that space flight environment and stress also affect some of immune systems in human. However, these cellular and molecular mechanisms are not fully understood (Figure). Our goal is to elucidate impacts of space flight on lymphoid organs and to identify their cellular and molecular mechanisms by utilizing murine space flight samples and data.