2016－2017 | Publicly Invited Research | Living in Space - Integral Understanding of life-regulation mechanism from "SPACE" | Grant-in-Aid for scientific Research on Innovative Area(2015-2019), MEXT, Japan

2016－2017 Publicly Invited Research

A01 Molecular and Cellular Foundations of Gravity Responses

Research Subject	Effects of gravity changes on thymic microenvironments
Research Group Leader	Taishin Akiyama Associate Professor, The Institute of Medical Science, The University of Tokyo

Research Subject	Mechanisms of skeletal muscle homeostasis maintenance through crosstalk between the sensory nervous system and skeletal muscle satellite cells
Research Group Leader	Hiroki Ochi Assistant Professor, Department of Physiology and Cell Biology, Tokyo Medical and Dental University Website http://www.bone-organcrosstalk-tmdu.jp/ (*Written in Japanese)

Research Subject	Identification of the gravity sensory system in bone homeostasis in medaka
Research Group Leader	Masahiro Chatani Assistant Professor, Department of Pharmacology, School of Dentistry, Showa University

Research Subject	Elucidation of the molecular mechanism underlying gravity-YAP-mediated 3D organogenesis -Toward generating a complex 3D organ in microgravity-
Research Group Leader	Makoto Seiki Professor, Systems Biochemistry in Pathology and Regeneration, Yamaguchi University Graduate School of Medicine Website http://ds.cc.yamaguchi-u.ac.jp/~biochem1/ENGLISHtop.html

Research Subject	Pathophysiological role of mitochondrial aconitase in unloading-mediated muscle atrophy
Research Group Leader	Takeshi Nikawa Professor, Graduate School of Medicine, Tokushima University Website http://www.tokushima-u.ac.jp/med/culture/seitaieiyou/ (*Written in Japanese)

Research Subject	Study on effects of the space environment on brain structures and functions of model vertebrate zebrafish
Research Group Leader	Koichi Kawakami Professor, National Institute of Genetics

Research Subject	Mechanism of homeostatic robustness by exercise to reduce health risk in space life
Research Group Leader	Takuro Numaga-Tomita Assistant professor, Okazaki Institute for Integrative Biology (National Institute for Physiological Sciences), National institutes of Natural Sciences

Research Subject	*Study for aging of C. elegans* in space**
Research Group Leader	Yoko Honda Research Fellow, Center for Advanced Biomedical Sciences, Research Institute for Science and Engineering, Waseda University)

A02 Influence of a Prolonged Stay in Space on Higher-order Homeostasis

Research Subject	Mechanisms underlying bone loss during spaceflight ~Elucidation of the regulatory mechanism for expression of an osteoclast differentiation factor, RANKL
Research Group Leader	Masahiro Shinohara Junior Associate Professor, Department of Systems BioMedicine, Tokyo Medical and Dental University

Research Subject	Immune System Plasticity and Failure in Response to Gravitational Changes - An Approach to Understanding Immunological Memory -
Research Group Leader	Yoichi Maekawa Professor, Graduate School of Medicine, Gifu University

Research Subject	Development of risk assessment and method of protection for inner ear impairment caused by possible physical stress in a closed space
Research Group Leader	Nobutaka Ohgami Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine

Research Subject	Effects of Confinement Stress on Homeostasis of the Mammalian Endocrine System and Metabolism
Research Group Leader	Wataru Nishimura Associate Professor, Department of Anatomy, Bio-imaging and Neuro-cell Science, Jichi Medical University Website http://www.jichi.ac.jp/anatomy/ (*Written in Japanese)

Research Subject	Epigenetic mechanisms understanding the responsiveness of skeletal muscles to physiological stimuli during an ultra-long-term stay in space
Research Group Leader	Fuminori Kawano Associate Professor, Graduate School of Health Sciences, Matsumoto University Website http://www.matsumoto-u.ac.jp/professors/graduate/health/post-9.php (*Written in Japanese)

Research Subject	Effectiveness of Artificial Gravity with Exercise on Spaceflight Deconditioning in Humans
Research Group Leader	Satoshi Iwase Professor, Department of Physiology, Aichi Medical University School of Medicine

Research Subject	Investigation of core technology for the food production in closed space under microgravity
Research Group Leader	Takuya Furuichi Associate Professor, Graduate School of Human Life Sciences, Nagoya University of Economics

Research Subject	Chronic effects of non-24 hour solar days
Research Group Leader	Jihwan Myung Research Scientist, Okinawa Institute of Science and Technology Graduate University

Research Subject	Understanding the health effects and susceptibility factors of circadian misalignment
Research Group Leader	Shingo Kitamura Section Chief, Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry

A03 Environmental Risks Expected in Space

Research Subject	Development of novel PDMS-based micro-nano device for monitoring DNA damage
Research Group Leader	Asako Nakamura Associate Professor, College of Science, Ibaraki University Website http://asakolab.sci.ibaraki.ac.jp/ (*Written in Japanese)

Research Subject	Differences in Radiation-induced DNA Damage Responses among Organs; Spatiotemporal Analyses Using Genetically Engineered Mice
Research Group Leader	Hiroshi Harada Professor, Radiation Biology Center, Kyoto University Website http://radiotherapy.kuhp.kyoto-u.ac.jp/biology/ (*Written in Japanese)

Research Subject	Biological Effects of Clustered DNA Damage Induced by Space Radiation
Research Group Leader	Hiroshi Ide Professor, Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University Website http://home.hiroshima-u.ac.jp/genechem/index2.html

Research Subject	Investigation of molecular mechanisms underlying the alterations in host-pathogen interaction during spaceflight
Research Group Leader	Mutsunori Shirai Professor, Vice-president, Department of Microbiology and Immunology, Yamaguchi University Graduate School of Medicine

Research Subject	Estimation of carcinogenic risk after exposure to space radiation by pathological and genomic analyses
Research Group Leader	Shizuko Kakinuma Director, Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology

B01 Cross-sectional/complementary studies

Research Subject	Hypothermia as a risk factor for memory consolidation
Research Group Leader	Michael Lazarus Associate Professor, International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba Website http://www.wpiiiislazaruslab.org/

Research Subject	Establishment of model mice for non-invasive monitoring of physiological effects in extreme environments
Research Group Leader	Yoshihiro Miwa Assistant professor, Faculty of Medicine, University of Tsukuba Website http://www.md.tsukuba.ac.jp/basic-med/pharmacology/miwa/index.html (*Written in Japanese)

Research Subject	Elucidation of molecular machinery essential for extremotolerant ability in tardigrades
Research Group Leader	Takekazu Kunieda Assistant Professor, Graduate School of Science, University of Tokyo Website http://www.biol.s.u-tokyo.ac.jp/users/saibou/kuma/ (*Written in Japanese)

Research Subject	Understanding the Mechanism of Maintaining Social Regulatory Functions under Unexpected Stress
Research Group Leader	Koji Shimada Specially-appointed Assistant Professor, Research Center for Child Mental Development, University of Fukui

Research Subject	Plant culture system for producing food, recycling materials and maintaining human health necessary for life support in space
Research Group Leader	Yoshiaki Kitaya Professor, Graduate School of Life and Environmental Sciences, Osaka Prefecture University

Research Subject	Visualizing cell function dynamics in virtual outer space
Research Group Leader	Asako Sakaue-Sawano Laboratory for Cell Function Dynamics, RIKEN Brain Science Institute Website http://cfds.brain.riken.jp/Fucci.html