Living in Space
Integral Understanding of life-regulation mechanism from "SPACE"

Differences in Radiation-induced DNA Damage Responses among Organs; Spatiotemporal Analyses Using Genetically Engineered Mice – Publicly Invited Research 2016－2017

1. A01 Akiyama
2. A01 Ochi
3. A01 Chatani
4. A01 Seiki
5. A01 Nikawa
6. A01 Kawakami
7. A01 Tomita
8. A01 Honda

1. A02 Shinohara
2. A02 Maekawa
3. A02 Ohgami
4. A02 Nishimura
5. A02 Kawano
6. A02 Iwase
7. A02 Furuichi
8. A02 Myung
9. A02 Kitamura

1. A03 Nakamura
2. A03 Harada
3. A03 Ide
4. A03 Shirai
5. A03 Kakinuma

1. B01 Lazarus
2. B01 Miwa
3. B01 Kunieda
4. B01 Shimada
5. B01 Kitaya
6. B01 Sawano

Research Subject	Differences in Radiation-induced DNA Damage Responses among Organs; Spatiotemporal Analyses Using Genetically Engineered Mice
Research Group Leader	Hiroshi Harada Professor, Radiation Biology Center, Kyoto University Website http://radiotherapy.kuhp.kyoto-u.ac.jp/biology/ (*Written in Japanese)
Research Collaborator(s)	Michio Yoshimura Assistant Professor, Graduate School of Medicine, Kyoto University Yoko Goto Assistant Professor, Graduate School of Medicine, Kyoto University Minoru Kobayashi Postdoctoral Fellow, Radiation Biology Center, Kyoto University

Several lines of research have reported that the radiosensitivity of cells differs among organs; this notion is based on the so-called Bergonie-Tribondeau's law. However, it remains largely unclear how and why tissue microenvironments influence the efficiency of both generating and repairing DNA damage. In our project, we intend to analyze the diversity of radiation-induced DNA damage responses among the major organs by creating genetically engineered mice that allow us to monitor DNA double-strand breaks in real-time. The ultimate goal of our project is to comprehensively understand the impact of space radiation on the human body.