Living in Space
Integral Understanding of life-regulation mechanism from "SPACE"

Programmed Research

A01 Molecular and Cellular Foundations of Gravity Responses

Research Subject	A01-1 Mechanosensing Mechanisms for Sensing Mechanical Stress Including Gravitational Changes
Research Group Leader	Keiji Naruse Professor, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Website http://www.okayama-u.ac.jp/user/med/phy2/ (*Partly written in Japanese)

Research Subject	A01-2 Mechanisms of Mechanostress Transmissions from Nerves to Muscles - Metabolism and Adaptive Responses
Research Group Leader	Atsushi Higashitani Professor, Graduate School of Life Sciences, Tohoku University Website http://www.ige.tohoku.ac.jp/genome/ (*Japanese)

Research Subject	A01-3 Understanding the Molecular Foundations of Load Dependency in the Development, Maintenance, and Atrophy of Skeletal Muscles
Research Group Leader	Atsuko Sehara-Fujisawa Cooperative Professor, Institute for Frontier Life and Medical Sciences, Kyoto University Website https://www.infront.kyoto-u.ac.jp/research/lab13/?lang=en

A02 Influence of a Prolonged Stay in Space on Higher-order Homeostasis

Research Subject	A02-1 Changes in the Cardiovascular Regulatory Mechanism due to Gravitational Variations and Confinement
Research Group Leader	Kenichi Iwasaki Professor, School of Medicine, Nihon University Website http://www.med.nihon-u.ac.jp/department/spacemed/ (*Japanese)

Research Subject	A02-2 Comprehensive Understanding of the Adaptive Response of Vestibular Plasticity and Strategies against Adaptation Disorders
Research Group Leader	Hironobu Morita Professor, Graduate School of Medicine, Gifu University Website http://www1.gifu-u.ac.jp/~physiol/ (*Japanese)

Research Subject	A02-3 Elucidation of a Homeostatic Control Mechanism of a Mental State and the Autonomic Nervous System under Unexpected Stress
Research Group Leader	Ichiyo Matsuzaki Professor, Faculty of Medicine, University of Tsukuba Website http://occup-aerospace-psy.org/ (*Japanese)

Research Subject	A02-4 Development of New Strategies to Regulate Sleep/Wakefulness in a Hyper-stressful Environment such as a Spacecraft
Research Group Leader	Hiroshi Nagase Professor, International Institute for Integrative Sleep Medicine, University of Tsukuba Website http://nagase.wpi-iiis.tsukuba.ac.jp/ (*Japanese)

Research Subject	A02-5 Comprehensive Understanding of Zero Gravity and Confinement Stress
Research Group Leader	Satoshi Furukawa Chief Developer, Human Spaceflight Technology Directorate, Japan AeroSpace Exploration Agency Website http://iss.jaxa.jp/en/kiboexp/theme/#medicine&technology

A03 Environmental Risks Expected in Space

Research Subject	A03-1 Multidisciplinary Analysis of the Effect of Low Fluence Particle Radiation on Animals and Biological Adaptations
Research Group Leader	Mitsuru Nenoi Director, Dept. of Safety Administration, National Institutes for Quantum and Radiological Science and Technology Website https://www.qst.go.jp/site/nirs-english/1371.html https://www.qst.go.jp/site/nirs-english/1366.html https://www.nirs.qst.go.jp/ENG/core/fph/index.html

Research Subject	A03-2 Acute Effects of Space Radiation with Different Radiation Qualities and Dose-rates
Research Group Leader	Akihisa Takahashi Professor, Gunma University Heavy Ion Medical Center (GHMC), Gunma University Website http://heavy-ion.showa.gunma-u.ac.jp/en/

Research Subject	A03-3 Microorganisms in a Confined Environment
Research Group Leader	Masao Nasu Professor, Graduate School of Pharmaceutical Sciences, Osaka Ohtani University Professor Emeritus, Osaka University Website http://www.phs.osaka-u.ac.jp/homepage/b017/kenkyu/ (*Japanese)